For two millennia, medicinal mushrooms have been mainstream in Asia. Now, America is taking notice and interest is rapidly "mushrooming." With the sprouting of this new industry follows issues of ethical quality claims between competing brands.

All medicinal mushroom species are plagued by this. Most fiercely debated is red reishi (Ganoderma lucidum), the most popular of all medicinal mushrooms. So this article will primarily focus on that species, but it's generally applicable to all species of medicinal mushrooms.

The first and perhaps obvious caution is to stay away from cheap mass-produced brands of medicinal mushrooms that may only contain dried and pulverized mushrooms, in which case the medicinal compounds are still inaccessible behind the mushrooms' cell walls.

Then there are the real therapeutic grade red reishi brands, which are produced with much more care. But even here there are big differences between brands. Each claims to be the best, of course, because they want to sell their product. So lets set the facts straight and be independently informed consumers.

Below are three common methods for extracting medicinal compounds from reishi. Each method results in different compounds. All groups have been shown to have therapeutic effects in scientific studies.

1. Water (Hot) Extraction (polysaccharides, etc.)

2. Alcohol Extraction (triterpenoids, etc.)

3. Fermentation (arabinoxylanes, etc.)

The water soluble compounds, primarily polysaccharides, are powerful anti-tumor agents, immune enhancers and strong antioxidants. [1]

Through alcohol extraction, we get triterpenoids, a large group of lipids with many sub-groups. Research shows triterpenoids help regulate clotting, blood pressure and cholesterol. More importantly, they are the anti-inflammatory compounds that are the reason why reishi often gets recommended for arthritis, asthma and allergies. [1]

Less researched are the "secondary metabolites" that come from fermenting reishi. "Secondary" because they result when the original medicinal compounds get broken down by bacteria. These new compounds have been shown to possess therapeutic properties that are unique, including immune enhancement, anti-tumor and blood-sugar regulation. [2]

This article is not meant to recommend any particular brand so none will be mentioned by name. But the author does know of two reishi companies (Japanese and American) that both claim only hot water extract of reishi is effective and that alcohol extracts are of no use.

Of course they do that to promote their own brand. In reality both hot water extract and alcohol extract contain unique medicinal compounds that are all very important.

When looking for the best reishi extract, find one that uses at least the first two extraction methods in combination: Hot Water and Alcohol Extraction. Even better may be a brand that includes all three methods listed.

Last but not least, remember to look at the form the reishi comes in. If the reishi is able to dissolve completely in water-based drinks like coffee, it's a safe bet that it only contains the water-soluble polysaccharides. An excellent choice as far as coffee goes but an incomplete reishi supplement because it does not include the anti-inflammatory triterpenoid compounds.

Alcohol tinctures, on the other hand, are well worth considering because they may be a blend of water and alcohol extracts. The way to tell is if the tincture is cloudy. When water-soluble polysaccharides get mixed with alcohol, they fall out of solution. Cloudiness in an alcohol tincture indicates high polysaccharide content. Just shake before taking. Tablets and capsules can contain hot water extract, alcohol extract or both. You need to find out from the manufacturer.

[1] Boh B, Berovic M, Zhang J, Zhi-Bin L, 2007. "Ganoderma lucidum and its pharmaceutically active compounds." Biotechnology Annu Rev 13:265-301.

[2] Tang YJ, Zhang W, Zhong JJ. "Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum." Bioresource Technology 2009 Mar;100(5):1852-9.